Aristolone content analysis in ficus auriculata as predicted apoptotic activity in hela cells

Authors

  • Kusmayra Ambarwati Research Standing Committee International Confederation of Midwives https://orcid.org/0000-0001-6081-0097
  • Miftahul Jannah Universitas Respati Jakarta
  • Asyifa Robiatul Adawiyah Universitas Respati Jakarta

DOI:

https://doi.org/10.31101/jhtam.1435
Abstract views 918 times

Keywords:

Aristolone, HeLa Cell, Apoptosis, Cancer

Abstract

Antioxidants and herbs have been scientifically proven to be one of the substances that can prevent cervical cancer. The incidence of cervical cancer in Indonesia is very high and is a vital cause of death of women in Indonesia. Every day 40-45 new cases emerge, which means 20-25 people die from cervical cancer in Indonesia. Several previous studies have shown that there are plants, fruits and seeds that contain high antioxidants and are believed to prevent and reduce pain due to cervical cancer. Besides, many herbs that also found in Indonesia are known to affect cancer cells. Ficus auriculata can find in Indonesia. However, not many people use the available natural resources that are suspected to prevent cervical cancer. This study was a preliminary study analyzed of Aristolone in Ara Fruit used as a prediction of apoptosis in HeLa cells. The results showed that the positive effect of Aristolone content in F. auriculata affected proliferation supported by previous studies.

Author Biographies

Kusmayra Ambarwati, Research Standing Committee International Confederation of Midwives

Indonesian Breastfeeding Mothers Association

Miftahul Jannah, Universitas Respati Jakarta

Indonesian Breastfeeding Mothers Association, Jakarta

Asyifa Robiatul Adawiyah, Universitas Respati Jakarta

Indonesian Breastfeeding Mothers Association, Jakarta

References

Ahmad. (2016). Evaluation of Rumex hastatus D. Don for cytotoxic potential against HeLa and NIH/ 3T3 cell lines: chemical characterization of chloroform fraction and identification of bioactive compounds. BMC Complementary and Alternative Medicine.

Gama – Sitosterol. (2019). National Center for Advancing Translational Sciences (NCATS).

Ghani, Jamil, & Ibrahim. (2019). . Polyamines Deficient Diet is a Complementary Strategy in Fighting Cancer: Analysis on Selected Medicinal Fruits. International Journal of Recent Technology and Engineering (IJRTE). doi:10.35940/ijrte.C1127.1083S219

Jamil, & Ghani. (2017). Ficus auriculata (fig) Extracts Induced Cell Cycle Profile Changes and Apoptosis Through Caspase-Independent Pathway in Human Lung Adenocarcinoma Cell Line, A549. 16.

Khodarahmi. (2011). Cytotoxic Effects of Different Extracts and Latex of Ficus carica L. on HeLa cell Line. Iranian Journal of Pharmaceutical Research. Iranian Journal of Pharmaceutical Research, 10(2), 273–277.

Limanan, Ferdinal, Salim, & Yulianti. (2108). Metanol Extract Leaves Ara Ficus Auriculata Lour. Jurnal Muara Sains, Teknologi, Kedokteran, dan Ilmu Kesehatan. ISSN-L 2579-6410.

Marrelli. (2015). Inhibitory effects of wild dietary plants on lipid peroxidation and on the proliferation of human cancer cells. Food and Chemical Toxicology. 86. http://dx.doi.org/10.1016/j.fct.2015.09.011

Memariani. (2016). Cytotoxic Effects Of Cyperus Longus On Pc-3 And Mcf7 Cancer Cell Lines. Oncology Letters. 11, 1353–1360. doi: 10.3892/ol.2015.4050

Ministry of Health. (2015). Ministry of Health (Data dan Informasi Kesehatan. Jakarta).

Mon. (2020). The uses of fig (Ficus) by five ethnic minority communities in Southern Shan State, Myanmar.Journal of Ethnobiology and Ethnomedicine. https://doi.org/10.1186/s13002-020-00406-z

Nogueira. (2020). Cyperus articulatus L. (Cyperaceae) Rhizome Essential Oil Causes Cell Cycle Arrest in the G2/M Phase and Cell Death in HepG2 Cells and Inhibits the Development of Tumors in a Xenograft Model. Molecules. doi:10.3390/molecules25112687

Polu. (2107). Assessment of free radical scavenging and anti-proliferative activities of Tinospora cordifolia Miers (Willd). BMC Complementary and Alternative Medicine.

Putthawan,Poaeman, A. (2017). Cytotoxic activity and apoptotic induction of some edible Thai local plant extracts against colon and liver cancer cell lines. Tropical Journal of Pharmaceutical Research. Tropical Journal of Pharmaceutical Research. http://dx.doi.org/10.4314/tjpr.v16i12.17

Qi. (2017). A new isoflavone from the roots of Ficus auriculata. Natural Product Research. http://dx.doi.org/10.1080/14786419.2017.1329728

Shao. (2014). Lactones from Ficus auriculata and their effects on the proliferation function of primary mouse osteoblasts in vitro. Bioorganic & Medicinal Chemistry Letters. http://dx.doi.org/10.1016/j.bmcl.2014.06.035

Shao. (2020). A new12-membered lactone from the stems of Ficus auriculata. Natural Product Research.

Siegel. (2016). Cancer statistics, 2016. CA Cancer J.Clin. doi: 10.3322/caac.21332

Wong. (2020). . Biological Activities of Selected Plants and Detection of Bioactive Compounds from Ardisia elliptica Using UHPLC-Q-Exactive Orbitrap Mass Spectrometry. Molecules.

Yin S. (2013). Therapeutic Applications of Herbal Medicines for Cancer Patients. Evid. Based Complement. Altern. Med. doi: 10.1155/2013/302426

Zhang. (2018). Molecular Phylogeny of the Ficus auriculata Complex (Moraceae). Phytotoxa. https://doi.org/10.11646/phytotaxa.362.1.3

Zhang. (2019). Taxonomic treatment of the Ficus auriculata complex (Moraceae) and typification of some related names. Phytotaxa. https://doi.org/10.11646/phytotaxa.399.3.4

Downloads

Published

2021-03-04

How to Cite

Ambarwati, K., Jannah, M., & Adawiyah, A. R. (2021). Aristolone content analysis in ficus auriculata as predicted apoptotic activity in hela cells. Journal of Health Technology Assessment in Midwifery, 4(1), 15–20. https://doi.org/10.31101/jhtam.1435

Issue

Vol. 4 No. 1 (2021): May

Section

Articles

License

Authors who publish with Journal of Health Technology Assessment in Midwifery agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC BY-SA 4.0) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.

Lisensi Creative Commons
Journal of Health Technology Assessment in Midwifery is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License..

SHARE THIS