Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice

Authors

  • Haryanto Haryanto STIK Muhammadiyah Pontianak, Indonesia https://orcid.org/0000-0002-3711-1885
  • Kanae Mukai Kanazawa University, Japan
  • Nakajima Yukari Kanazawa University, Japan
  • Mayumi Okuwa Kanazawa University, Japan
  • Cau Kim Jiu Khon Kaen University, Thailand
  • Junko Sugama Kanazawa University, Japan
  • Toshio Nakatani Kanazawa University, Japan

DOI:

https://doi.org/10.31101/jhtam.912

Keywords:

indonesian honey, japanese honey, wound healing, hydrocolloid dressing,

Abstract

The purpose of this study is to evaluate and clarify the effect of Indonesian honey, two types of Japanese honey and hydrocolloid dressing on wound healing process. Four groups of male mice were treated to produce two circular full-thickness skin wounds on the dorsum. They were then randomly allocated to receive daily Indonesian honey, Japanese honey (Buckwheat and Acacia honey) or hydrocolloid dressing as a control for treatment application. Macroscopic findings were observed from day 0 to 14 after wounding. Microscopic evaluation was assessed using qualitative analysis. The ratios of wound areas for honey groups on day 3 and 7 were smaller than those of the control group. Wound areas of honey groups gradually decreased to almost the same wound area as the control group on day 14, while the wound area of the control group peaked on day 5 and rapidly decreased until day 14. Microscopic finding that Indonesian honey was different with Japanese honey especially Buckwheat honey.

Author Biographies

Kanae Mukai, Kanazawa University

Department of Clinical Nursing, Graduate School of Medical Sciences

Nakajima Yukari, Kanazawa University

Advanced Health Care Science Research Unit Innovative Integrated Bio-Research Core Institute for Frontier Science Initiative

Mayumi Okuwa, Kanazawa University

Advanced Health Care Science Research Unit Innovative Integrated Bio-Research Core Institute for Frontier Science Initiative

Cau Kim Jiu, Khon Kaen University

Faculty Of Nursing

Junko Sugama, Kanazawa University

Advanced Health Care Science Research Unit Innovative Integrated Bio-Research Core Institute for Frontier Science Initiative

Toshio Nakatani, Kanazawa University

Advanced Health Care Science Research Unit Innovative Integrated Bio-Research Core Institute for Frontier Science Initiative

References

Bergman, A., Yanai, J., Weiss, J., Bell, D., & David, M. P. (1983). Acceleration of wound healing by topical application of honey: An animal model. The American Journal of Surgery, vol.145(issue.3), 374–376.

Fukuda, M., Kobayashi, K., & Hirono, Y. et al. (2011). Jungle honey enhances immune function and antitumor activity. Evidence Based Complementary and Alternative Medicine, 2011, 8.

Ghaderi, R & Afshar, M. (2004). Topical application of honey for treatment of skin wound in mice. Iran Journal Medical Sciences, 29(4), 185–188.

Gheldof N, Wang, X.H, E. N. J. (2002). Identification and quantification of antioxidant components of honeys from various floral sources. J Agric Food Chem, 50, 5870–5877.

Gheldof N, E. N. J. (2002). Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J Agric Food Chem, 50, 3050–3055.

Haryanto., Urai, T., Mukai, K., Suriadi, Sugama, J., Nakatani, T. (2012). Effectiveness of Indonesian Honey on the Acceleration of Cutaneous Wound Healing: An Experimental Study in Mice. WOUNDS, 24(4), 110–119.

Iftihkar, F., Arshad, M., Rasheed, F., Amraiz, D., Anwar, P., & Gulfraz, M. (2010). Effects of Acasia honey on wound healing in various rat models. Phytotherapy Research, vol.24(4), 583–586.

Mayers, L and Hudson, S. L. (2013). Wound Care: Getting to the Depth of the Tissue, Lakeway Texas: The National Center of Continuing Education. 1–16.

Molan, P & Rhodes, T. (2015). Honey: A Biologic Wound Dressing. WOUNDS, 27(issue. 6), 141–151.

Moore, O. A., Smith, L. A., Campbell, F., Seers, K., McQuay, H.J., Moore, R. A. (2001). Systematic review of the use of honey as a wound dressing. BMC Complementary and Alternative Medicine, vol.1(no.2).

Nakajima, Y., Nakano, Y., Fuwono, S. et al. (2013). Effect of Three Type of Japanese Honey on Full-Thickness Wound in Mice. Evidence-Based Complementary and Alternative Medicine, vol.2013, 11.

Nisbet, H.O., Nisbet, C., Yarim, M., Guler, A., & Ozak, A. (2010). Effect of three types of honey on cutaneous wound healing. WOUNDS, vol.22(no.11), pp.275-283.

Pawar, R.S., Chaurasiya, P.K., Rajak, H., Singour, P.K., Toppo, F. A., & Jain, A. (2013). Wound healing activity of Sida cordifolia Linn in rats. Indian J Pharmacol, vol 45, 474–478.

Sari, Y., Purnawan, I., Kurniawan, D.W., & Sutrisna, E. (2018). A Comparative Study of the Effect of Nigella sativa Oil Gel and Aloe Vera Gel on Wound Healing in Diabetic Rats. Journal of Evidence-Based Integrative Medicine, vol.23, pp.1-6.

Shaw, T. J and Martin, P. (2009). Wound Repair at A Glance. Journal of Cell Science, 122(18), 3209–3213.

Tahir, T., Bakri, S., Patellongi, I., Aman, M., Miskad, U.A., Maryunis., Yusuf, S., Rahayu, A. I., Syam, A.D., & H. (2017). Evaluation of Topical Red Dragon Fruit Extract Effect (Hylocereus Polyrhizus) on Tissue Granulation and Epithelialization in Diabetes Mellitus (DM) and Non-DM Wister Rats: Pre Eliminary Study. International Journal of Sciences: Basic and Applied Research, 32, pp.309-320.

Tarawan, V.M., Mantilidewi, K. I., & Sutedja, E. (2016). Coconut Shell Liquid Smoke Promotes Burn Wound Healing. (38), pp.1-5.

Tonks A, Cooper R.A, Price A.J, Molan P.C, & J. K. P. (2001). Stimulation of TNF-ï¡ release in monocytes by honey. Cytokines, 14, 240–242.

Tonks A.J, Cooper R.A, Jones KP, Blair S, Parton J, & T. A. (2003). Honey stimulates inflammatory cytokines production from monocytes. Cytokines, 21, 242–247.

Zohdi, R.M., Zaria, Z.A.B., Yusof, N., Mustapha, M & Abdullah, M. N. . (2012). Gelam (Melaleuca spp.) honey-based hydrogel as burn wound dressing. Evidence-Based Complementary and Alternative Medicine, 2012, 7.

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Published

2019-11-04

How to Cite

Haryanto, H., Mukai, K., Yukari, N., Okuwa, M., Jiu, C. K., Sugama, J., & Nakatani, T. (2019). Evaluation of Indonesian and two types of Japanese honey on the acceleration of cutaneous wound healing: an experimental study in mice. Journal of Health Technology Assessment in Midwifery, 2(2), 80–88. https://doi.org/10.31101/jhtam.912

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