Correlation between albumin creatinine ratio and hypertension in type 2 diabetes


  • Vitasari Indriani Faculty of Medicine Jenderal Soedirman University Purwokerto, 53112
  • Wahyu Siswandari Faculty of Medicine Jenderal Soedirman University Purwokerto, 53112
  • Pugud Samudro Faculty of Medicine Jenderal Soedirman University Purwokerto, 53112
  • Nor Sri Inayati Faculty of Medicine Jenderal Soedirman University Purwokerto, 53112

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ACR, Hypertension, Type 2 Diabetes Mellitus


Hypertension is often found in patients with type 2 diabetes. Albumin Creatinine Ratio (ACR) is used to detect early symptoms of kidney disease in patients with type 2 diabetes. The aim of this study is to determine the correlation between ACR and hypertension, as well as its relationship with other risk factors in type diabetes patients 2. Data were collected from 112 diabetic patients at PROLANIS FKTP Banyumas to see ACR and blood pressure. The results showed that poor glycemic control could be one of the risk factors. It can be concluded that detecting kidney dysfunction through ACR and starting treatment as early as possible can avoid the worst possibilities in type 2 diabetes patients.


American College of Cardiology. (2017). Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults. Clinical Practice Guidelines. 1(1): 4-28

American Diabetes Association. (2018). Standards of Medical Care in Diabetes. Diabetes Care. 33 (1) : 11-4.

Audehm, R., Arthur, I., Barlow, J., Kennedy, M., Kilov, G., Leow, S., et al. (2014). General Practice Management of Type 2 Diabetes. The Royal Australian

College of General Practitioners and Diabetes Australian. pp :47-51.

Bawazier LA. (2014). Proteinuria dalam Buku Ajar Ilmu Penyakit Dalam. Edisi VI. Jakarta: IPD FK UI. hlm: 956.

Carey, R.M. (2007). Hypertension and Hormone Mechanisms. Humana Press. Totowa. New Jersey.

Cho, N. H. et al. High Blood Pressure and Its Association With Incident Diabetes Over 10 Years in the Korean Genome and Epidemiology Study (KoGES). Diabetes Care 38, 1333–1338, (2015).

Dennison-himmelfarb C., Handler J. and Lackland D.T. (2014). Evidence Based Guideline for the Management of High Blood Pressure in Adults Report From the Panel Members Appointed to the Eighth Joint National Committee (JNC 8). American Medical Assosiation. 1097. 1–14.

Dutta, D., Choudhuri, S., Mondal, S. A., Mukherjee, S. & Chowdhury, S. Urinary albumin: creatinine ratio predicts prediabetes progression to diabetes and reversal to normoglycemia: role of associated insulin resistance, infammatory cytokines and low vitamin D. J Diabetes 6, 316–322, (2014).

Fatimah, Restyana Noor. 2015. Diabetes Melitus Tipe 2. J Majority. 4(5) hal. 93-101.

Garnita, D. (2012). Faktor Risiko Diabetes Melitus di Indonesia Analisa Data

Sukerti 2007. Skripsi. Depok : FKM UI.

Guyton, A.C., Hall, J.E. (2008). Buku Ajar Fisiologi Kedokteran. Jakarta: EGC.

Hakim, Buraerah H., Abdullah, A. Zulkifli, Hanis, M. (2010). Analisis Faktor Risiko Diabetes Melitus Tipe 2 di Puskesmas Tanrutedong, Sidenreng Rappang, 2007. Jurnal Kedokteran Indonesia, 35 (4).

Hendromartono. (2014). Nefropati Diabetik. Buku Ajar Ilmu Penyakit Dalam. Edisi VI Jilid II. Jakarta: Pusat Penerbit FKUI. hlm :2386-396

International Diabetes Federation (IDF). (2017). Clinical Practice Recommendations for Managing Type 2 Diabetes in Primary Care. Jurnal online [diunduh 2 April 2018]. Tersedia dari:

Joshi KR, Ashish G, Dipendra RP, Keshab P. (2013). Serum Creatinine and Urine Microalbumin Level in Hypertensive and Non hypertensive Patients. Medical Journal of Shree Birendra Hospital. 12: 27-29.

Kara, A. (2012). Renal Function. Clinical chemistry 6th ed. Philadephia: Wolters Kluwer.

Koubaa, A., Sriha BA., Harzallah N., Bellaleh A., Sahtout M., Younes K., et al. (2016). Screening for Nephropathy in Diabetes Melitus: Is Micral-Test Valid among All Diabetics?. International Journal of Chronic Diseases.

Lehman R, Krumholz HM. (2009). Tight control of blood glucose in long standing type 2 diabetes. BMJ. pp :338-800.

Mihardja L, Soetrisno U, Soegondo S. (2014). Prevalence And Clinical Profile Of Diabetes melitus In Productive Aged Urban Indonesians. J Diabetes Invest. (5) :507–512.

Muslim, A. (2014). Jumlah Leukosit dengan Kadar Mikroalbumin Urin Penderita Diabetes Melitus. Jurnal Kesehatan. 1 (1): 40-43.

Mutmainah, I. (2013). Hubungan Kadar Gula Darah dengan Hipertensi pada Pasien Diabetes melitus Tipe 2 di Rumah Sakit Umum Daerah Karanganyar. Karanganyar.

Paputungan, S.R., Sanusi, H. (2014). Peranan Pemeriksaan Hemoglobin A1c pada Pengelolaan Diabetes Melitus. CDK-220. 41(9): 650-655.

Pilz, S. et al. Insulin sensitivity and albuminuria: the RISC study. Diabetes Care 37, 1597–1603, (2014)

Welsh, G. I. & Coward, R. J. Podocytes, glucose and insulin. Current opinion in nephrology and hypertension 19, 379–384, https://doi. org/10.1097/MNH.0b013e32833ad5e4 (2010)