Analysis of the effect of age and residence on the incidence of Giant Cell Tumors

Authors

  • Yuni Prastyo Kurniati -
  • Ikhya' Izatus Zahro
  • Yusuf Alam Romadhon

DOI:

https://doi.org/10.31101/ijhst.v5i2.3259
Abstract views 22 times

Keywords:

age; bone; giant cell tumor; residence

Abstract

Giant cell tumors are benign neoplasms that damage bone and often recur and have aggressive lesions. Benign tumors that can transform into malignant, aggressive, and able to metastasize to other organs.These tumors range from 3-8% of primary bone tumors in Western populations and as many as 20% in Asian countries. Risk factors for this disease are more common in women and at the age of the second to fourth decade. However, there are differences about the distribution of rural and urban areas between countries, as well as the age distribution of patients with these tumors in some countries. The purpose of this study was to analyze the effect of age and residence on the occurrence of Giant Cell Tumor. This study used a cross-sectional research design. The study sample was a histopathology preparation taken from 107 patient medical record data according to inclusion criteria using purposive sampling techniques. The results of the study found subjects with the most GCT were found in the high-risk age group (age range 20 to 50 years) of 67.3% and most of them lived in urban areas as much as 81.3%. Fisher's test showed an influence of age on the incidence of giant cell tumors (p = 0.007) and no influence between residence and the incidence of giant cell tumors (p = 0.262). The conclusion of this study is that age has a significant effect on the occurrence of Giant cell tumors. Meanwhile, residence does not affect the occurrence of Giant cell tumors.

References

Amanatullah, D. F., Clark, T. R., Lopez, M. J., Borys, D., & Tamurian, R. M. (2014). Giant cell tumor of bone. Orthopedics, 37(2), 112–120. https://doi.org/10.3928/01477447-20140124-08

Amelio, J. M., Rockberg, J., Hernandez, R. K., Sobocki, P., Stryker, S., Bach, B. A., Engellau, J., & Liede, A. (2016). Population-based study of giant cell tumor of bone in Sweden (1983-2011). Cancer Epidemiology, 42, 82–89. https://doi.org/10.1016/j.canep.2016.03.014

Avnet, S., Salerno, M., Zini, N., Alberghini, M., Gibellini, D., & Baldini, N. (2013). Sustained autocrine induction and impaired negative feedback of osteoclastogenesis in CD14+ cells of giant cell tumor of bone. American Journal of Pathology, 182(4), 1357–1366. https://doi.org/10.1016/j.ajpath.2012.12.021

Badan Pusat Statistik. (2020). Peraturan Kepala BPS No 120 Tahun 20220 Tentang Klasifikasi Desa, Perkotaan, dan Perdesaan di Indonesia 20201, Buku 2, Jawa.

Broehm, C. J., Inwards, C. Y., Al-Ibraheemi, A., Wenger, D. E., Jenkins, S. M., Jin, L., Oliveira, A. M., Zreik, R. T., Carter, J. M., Boland, J. M., Boland, J. M., & Fritchie, K. J. (2018). Giant Cell Tumor of Bone in Patients 55 Years and Older. American Journal of Clinical Pathology, 149(3), 222–233. https://doi.org/10.1093/ajcp/aqx155

Chakarun, C. J., Forrester, D. M., Gottsegen, C. J., Patel, D. B., White, E. A., & Matcuk Jr, G. R. (2013). Giant cell tumor of bone: review, mimics, and new developments in treatment. Radiographics, 33(1), 197–211.

Chenliang, L., Zhenqun, Z., & Wanlin, L. (2020). The role of OPG/RANKL/RANK signaling pathway in the pathogenesis of giant-cell tumor of bone. Chinese Journal of Tissue Engineering Research, 24(23), 3723–3729. https://doi.org/10.3969/j.issn.2095-4344.2694

Desrianta, I. G. N., & Wiratnaya, I. G. E. (2020). Prevalensi Tumor Tulang Jinak Di Rumah Sakit Umum Pusat Sanglah Denpasar Tahun 2013-2015. Medika Udayana, 9(11), 110–114.

di Carlo, F. S., Whyte, M. P., & Gianfrancesco, F. (2020). The two faces of giant cell tumor of bone. Cancer Letters, 489, 1–8.

Futriani, Muhammad P. Johan, Ni Ketut Sungowati, Andi A. Zainuddin, Djumadi Achmad, & Upik A. Miskad. (2022). Clinical Characteristics of Giant Cell Tumour of Bone in Makassar, Indonesia. International Journal of Sciences: Basic and Applied Research (IJSBAR), 62(2), 177–181. https://www.gssrr.org/index.php/JournalOfBasicAndApplied/article/view/14103

Gunasegaran, K., Irawan, M. N. S. B., & Yantisetiasti, A. (2016). Epidemiology of Giant Cell Tumor in Dr. Hasan Sadikin General Hospital Bandung from 2010-2013. Althea Medical Journal, 3(2), 244–247.

Herdini, C., Yudistira, D., & Indrasari, S. R. (2022). Maxillary Giant Cell Tumor in Jogjakarta, Indonesia: A Case Report. 2nd Global Health and Innovation in Conjunction with 6th ORL Head and Neck Oncology Conference (ORLHN 2021), 59–61.

Hu, P., Zhao, L., Zhang, H., Yu, X., Wang, Z., Ye, Z., Wu, S., Guo, S., Zhang, G., & Wang, J. (2016). Recurrence rates and risk factors for primary giant cell tumors around the knee: a multicentre retrospective study in China. Scientific Reports, 6(1), 36332.

Isidor, B., Odri, G., Gouin, F., & Heymann, M.-F. (2015). Genetics of giant cell tumors of bone. In Bone Cancer: Primary Bone Cancers and Bone Metastases: Second Edition. https://doi.org/10.1016/B978-0-12-416721-6.00029-7

Kementerian Kesehatan Republik Indonesia. (2019). Laporan Nasional Riset Kesehatan Dasar 2018.

Kim, W.-J., Kim, S., Choi, D.-W., Lim, G.-H., & Jung, S.-T. (2021). Characteristics of giant cell tumor of the bone in pediatric patients: Our 18-year, single-center experience. Children, 8(12). https://doi.org/10.3390/children8121157

Kurniati, Y. P. (2021). Giant Cell Tumor Of Small Bone: Kasus Tumor Tangan yang langka. Prosiding University Research Colloquium, 958–965.

Larsson, S. E., Lorentzon, R., & Boquist, L. (1975). Giant-cell tumor of bone. A demographic, clinical, and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958 through 1968. JBJS, 57(2). https://journals.lww.com/jbjsjournal/fulltext/1975/57020/giant_cell_tumor_of_bone__a_demographic,_clinical,.7.aspx

Liede, A., Bach, B. A., Stryker, S., Hernandez, R. K., Sobocki, P., Bennett, B., & Wong, S. S. (2014). Regional Variation and Challenges in Estimating the Incidence of Giant Cell Tumor of Bone. JBJS, 96(23). https://journals.lww.com/jbjsjournal/fulltext/2014/12030/regional_variation_and_challenges_in_estimating.9.aspx

Liede, A., Hernandez, R. K., Tang, E. T., Li, C., Bennett, B., Wong, S. S., & Jandial, D. (2018). Epidemiology of benign giant cell tumor of bone in the Chinese population. Journal of Bone Oncology, 12(July), 96–100. https://doi.org/10.1016/j.jbo.2018.07.003

Lin, F., Hu, Y., Zhao, L., Zhang, H., Yu, X., Wang, Z., Ye, Z., Wu, S., Guo, S., & Zhang, G. (2016). The epidemiological and clinical features of primary giant cell tumor around the knee: A report from the multicenter retrospective study in china. Journal of Bone Oncology, 5(1), 38–42.

López-Pousa, A., Broto, J. M., Garrido, T., & Vázquez, J. (2015). Giant cell tumour of bone: new treatments in development. Clinical and Translational Oncology, 17(6), 419–430. https://doi.org/10.1007/s12094-014-1268-5

Maulida, A. I., Ramzi, A., Kayla, B. G., Nadila, C., Salsabila, D., Anggy, F., Fesmia, H. L., Rahma, J. A., Putri, T. A. K., & Fakar, W. A. (2023). Giant Cell Tumor: Pathogenesis and Clinical Manifestation. Jurnal Biologi Tropis, 23(4b), 193–199.

Noh, B.-J., & Park, Y.-K. (2018). Giant cell tumor of bone: updated molecular pathogenesis and tumor biology. Human Pathology, 81, 1–8. https://doi.org/10.1016/j.humpath.2018.06.017

Orosz, Z., & Athanasou, N. A. (2017). Giant Cell–Containing Tumors of Bone. Surgical Pathology Clinics, 10(3), 553–573. https://doi.org/10.1016/j.path.2017.04.004

Palmerini, E., Picci, P., Reichardt, P., & Downey, G. (2019). Malignancy in Giant Cell Tumor of Bone: A Review of the Literature. Technology in Cancer Research & Treatment, 18, 1533033819840000. https://doi.org/10.1177/1533033819840000

Pradana, I. P. G. P., & Edward, M. (2021). Giant cell tumor of the ribs: a case report. Journal Orthopaedi and Traumatology Surabaya, 10(1), 32–38. 10.20473/joints.v10i1.2021.32-38

Pujani, M., Bahadur, S., Jairajpuri, Z. S., Jetley, S., & Jameel, J. (2015). Giant Cell Tumor Bone in an Elderly Male- an Unusual Case Misdiagnosed on MRI as a Malignant Sarcoma. Indian Journal of Surgical Oncology, 6(3), 285–287. https://doi.org/10.1007/s13193-015-0408-x

Pujiati, A. (2009). Analisis Kawasan Andalan in Central Java. Analisis Kawasan Andalan Di Jawa Tengah Analisis Kawasan Andalan in Central Java AMIN, 11(2), 117–128.

Putra, I. K. B. A., Sumadi, I. W. J., Sriwidyani, N. P., & Ekawati, N. P. (2021). Karakteristik Klinikopatologi Giant Cell Tumor Tulang di RSUP Sanglah Denpasar Bali tahun 2008 - 2018. Jurnal Medika Udayana, 24–27.

Raharjo, P., & Setiawati, R. (2022). Diagnosis of bone giant cell tumor in elderly patient: A case report of an unusual case. Annals of Medicine and Surgery, 79, 104111.

Shibuya, I., Takami, M., Kawamoto, M., Karakawa, A., Nakamura, S., & Kamijo, R. (2020). Immunohistochemical analysis of the distribution of rankl-expressing cells and the expression of osteoclast-related markers in giant cell tumor of bone. Journal of Hard Tissue Biology, 29(3), 137–146. https://doi.org/10.2485/jhtb.29.137

Sobti, A., Agrawal, P., Agarwala, S., & Agarwal, M. (2016). Giant cell tumor of bone-an overview. Archives of Bone and Joint Surgery, 4(1), 2.

Turyanti, A., Tania, J., Edvin, A., & Erliza, N. (2016). Analisis Pola Dispersi Partikulat Dan Sulfurdioksida Menggunakan Model Wrfchem Di Sekitar Wilayah Industri Tangerang Dan Jakarta. Jurnal Manusia Dan Lingkungan, 23(2), 169–178.

Verschoor, A. J., M G Bovée, J. V, L Mastboom, M. J., Sander DIJKSTRA, P. D., J Van De Sande, M. A., & Gelderblom, H. (2018). Incidence and demographics of giant cell tumor of bone in The Netherlands: First nationwide Pathology Registry Study. Acta Orthopaedica, 89(5), 570–574. https://doi.org/10.1080/17453674.2018.1490987

World Health Organization. (2018). WHO Classification of Tumors.

Zhang, X.-P., Lu, X.-C., Wang, L.-L., Wei, J.-Q., Yan, J., Shao, X.-N., Che, Y.-Y., & Cheng, J.-L. (2021). Giant Cell Tumors of Bone in Patients Aged 18 Years Old or Younger: Imaging Features and Tumor Characteristics. International Journal of General Medicine, 8389–8397.

Zhu, X., Huang, R., Hu, P., Yan, P. D., Zhai, S. A., Zhang, J. F., Zhuang, J. E., Yin, H. A., Meng, T. F., Yang, D. A., & Huang, Z. (2021). Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population. https://doi.org/10.12659/MSM.929154

Downloads

Published

2023-11-30

How to Cite

Kurniati, Y. P., Zahro, I. I., & Romadhon, Y. A. (2023). Analysis of the effect of age and residence on the incidence of Giant Cell Tumors. International Journal of Health Science and Technology, 5(2), 200–208. https://doi.org/10.31101/ijhst.v5i2.3259

Issue

Section

Original Research

SHARE THIS

Most read articles by the same author(s)